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Small, regular doses. There are some exceptions, but usually with vape pens there does seem to be a consistent element of diminishing returns. relief (2:1 THC ratio) The 2:1 THC to CBD ratio is becoming quite popular with consumers and patients alike, and the “relief” pen capitalizes The O.Pen Vape uses plastic cartomizers which are definitely not the healthiest option. As such, it is not recommended that you use the plastic cartridges more The oil in the pen is not as pure as it could be; I’ve seen products with much higher mg of THC or CBD per mL.